|
KMID : 0984720040360030127
|
|
Infection and Chemotherapy
2004 Volume.36 No. 3 p.127 ~ p.131
|
|
|
Failure of Cephalosporin Treatment for Bloodstream Infection Caused by Apparently Susceptible Klebsiella pneumoniae which Produced DHA-1β-Lactamase Induced by Clavulanic Acid
|
|
Kang Cheol-In
Pai Hyun-Joo
Kim Sung-Han
Kim Hong-Bin
Oh Myoung-Don
Kim Eui-Chong
Choe Kang-Won
|
|
|
Abstract
|
|
|
Backgroud : The therapeutic option is limited for the infections caused by organisms producing plasmidmediated AmpC beta-lactamases, incicasingly identified worldwide. Two sporadic patients with bacteremia caused by K pneumoniae possessing an unusual inducible 8 -lactam resistant phenotype were found in a university hospital.
Materials & Methods : We conducted antibiotic susceptibility test according to NCCLS guideline. Also, we characterized 8-lactamase by isoelectric focusing.
Results : DHA-1 gene conferred the resistant phenotype. The patients had experienced treatment failure when treated with extended-spectnim cephalosporin. For the isolates the cephalosporin resistance was induced by clavulanic acid (and cefoxitin).
Conclusion : Theses results suggest that the extended-spectrum cephalosporins might not provide optimal therapeutic option for inducible DHA-1-producing K pneumoniae infection, even when the pathogens are susceptible in vitro.
|
|
|
KEYWORD
|
|
|
Klebsiella, β-lactamase, Cephalosporin resistance
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|